MGMT Methylation Status: The Advent of Stratified Therapy in Glioblastoma?
نویسندگان
چکیده
منابع مشابه
MGMT Methylation Status: The Advent of Stratified Therapy in Glioblastoma?
Glioblastomas are the most malignant gliomas with median survival times of only 15 months despite modern therapies. All standard treatments are palliative. Pathogenetic factors are diverse, hence, stratified treatment plans are warranted considering the molecular heterogeneity among these tumors. However, most patients are treated with "one fits all" standard therapies, many of them with minor ...
متن کاملPersonalized treatment strategies in glioblastoma: MGMT promoter methylation status
The identification of molecular genetic biomarkers considerably increased our current understanding of glioma genesis, prognostic evaluation, and treatment planning. In glioblastoma, the most malignant intrinsic brain tumor entity in adults, the promoter methylation status of the gene encoding for the repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) indicates increased efficacy of cu...
متن کاملPrognostic Role of Methylation Status of the MGMT Promoter Determined Quantitatively by Pyrosequencing in Glioblastoma Patients
OBJECTIVE This study investigated whether pyrosequencing can be used to determine the methylation status of the MGMT promoter as a clinical biomarker using relatively old archival tissue samples of glioblastoma. We also examined other prognostic factors for survival of glioblastoma patients. METHODS The available study set included formalin-fixed paraffin-embedded (FFPE) tissue from 104 patie...
متن کاملGlioblastoma and the significance of MGMT gene methylation
Keywords Chemotherapy Glioblastoma MGMT gene Radiotherapy Temozolomide In this research Glioblastoma has been studied as one of the most common brain tumors and a short review of the available therapeutic methods have presented including surgery, radiotherapy, chemotherapy and particularly adjuvant chemotherapy with temozolomide, as the most effective developed treatment. Moreover, MGMT gene pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Disease Markers
سال: 2007
ISSN: 0278-0240,1875-8630
DOI: 10.1155/2007/159242